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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
32.73
Human Site:
S109
Identified Species:
51.43
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Chimpanzee
Pan troglodytes
XP_509323
803
92478
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Rat
Rattus norvegicus
Q66HD0
804
92752
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
S127
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Chicken
Gallus gallus
P08110
795
91537
S108
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Frog
Xenopus laevis
NP_001083114
805
92996
S109
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Zebra Danio
Brachydanio rerio
Q90474
725
83300
E83
E
L
I
P
D
Q
K
E
R
T
L
T
I
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
T76
I
P
N
K
T
A
G
T
L
T
I
I
D
T
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
G61
E
P
S
E
L
D
T
G
K
E
L
F
I
K
I
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
N108
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
F74
V
N
A
Q
P
E
L
F
I
R
L
V
P
D
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
N110
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
I64
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
100
13.3
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
100
20
N.A.
20
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
7
54
0
14
54
0
14
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
14
7
0
0
54
0
14
54
7
20
7
% D
% Glu:
20
54
7
20
0
7
0
7
0
7
0
0
0
0
7
% E
% Phe:
14
0
0
0
0
0
7
7
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
54
0
14
0
7
7
7
7
7
14
60
7
% I
% Lys:
0
0
0
7
0
0
7
0
7
0
0
0
60
7
20
% K
% Leu:
0
20
54
0
20
7
7
0
7
0
74
0
14
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
0
0
54
0
14
0
0
0
0
0
0
0
% N
% Pro:
0
14
0
14
7
0
0
0
0
0
0
7
7
7
0
% P
% Gln:
0
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% Q
% Arg:
54
0
14
0
0
0
0
0
14
7
0
0
0
0
54
% R
% Ser:
0
0
7
0
54
0
14
54
0
14
0
0
0
0
0
% S
% Thr:
0
7
0
0
7
0
7
7
0
14
7
7
0
7
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _